Best Hyaluronic Acid Supplement: How Much to Take Per Day and Benefits

THE'hyaluronic acid is a substance naturally present in our body, known above all for its ability to bind water and for the role it plays in the skin, joints and other tissues. It is one of the most used ingredients in moisturizing cosmetics and aesthetic medicine treatments, but in recent years it has also attracted growing interest in the form of a food supplement.

The hyaluronic acid supplements are studied mainly for their possible effects on skin hydration, skin elasticity and joint well-being. The available research offers interesting results, especially in the dermatological field, even if not all the hypothesized benefits have been confirmed with the same level of evidence.

But what happens when we take hyaluronic acid orally? What differences exist with respect to creams, serums and fillers? After how long can any results be observed and what characteristics should a good supplement have?

In this guide we delve into properties, benefits, dosages, side effects and contraindications of hyaluronic acid, analyzing the scientific studies and explaining how to choose between the different formulations available.

What is hyaluronic acid and what is it used for in our body?

Hyaluronic acid, called also hyaluronan, is a polysaccharide belonging to the glycosaminoglycan family. It is a long molecule made up of the repetition of two sugar units, naturally present in the extracellular matrix of numerous tissues.

One of its most important characteristics is the ability to interact with large quantities of water, contributing to the hydration and viscoelastic properties of the environments in which it is found.

This function takes on different characteristics depending on the tissue:

• In the skin: participates in maintenance of hydration, the organization of the extracellular matrix and the mechanical properties of the tissues.
• In the joints: is a fundamental component of the synovial fluid, which contributes to the lubrication of the joint surfaces.
• In the eyes: is present in ocular structures and is also used in specific preparations ophthalmic.
• In connective tissues: participates in the organization processes of the extracellular matrix and in the physiological responses involved in tissue repair.

The body continuously produces hyaluronic acid through specific cellular processes. The molecule is also degraded and renewed: it therefore does not constitute an immobile reserve, but is part of a dynamic system.

Why does hyaluronic acid decrease with age?

With aging, both the quantity and the organization of the hyaluronic acid present in the tissues change. In the skin, these transformations are accompanied by other modifications, such as the progressive alteration of collagen, elastin and the extracellular matrix.

The result can be less elastic, thinner skin or more prone to the appearance of wrinkles and expression lines.

Age, however, is not the only factor involved. Repeated exposure to ultraviolet rays, smoking, certain environmental conditions and individual characteristics also influence the skin aging process.

How does hyaluronic acid taken orally work?

When a cosmetic containing hyaluronic acid is applied, the action depends on the characteristics of the formulation and the interaction of the product with the skin surface. However, when you take a supplement, the path is different.

The ingested hyaluronic acid passes through the digestive system, where it can be partially degraded into smaller fragments. Research suggests that some digestion products can be absorbed and participate in biological processes, while other possible mechanisms involve interactions with the intestinal environment.

This does not mean that a hyaluronic acid capsule reaches the face or knees directly and necessarily retains the original structure. The metabolism of the molecule is more complex and several steps are still being studied.

Is hyaluronic acid from supplements absorbed?

Experimental and clinical research supports the biological plausibility of the activity of hyaluronic acid taken orally. However, the fate of the molecule also depends on the molecular weight, the formulation and the digestive processes.

Precisely for this reason it is not enough to know that a supplement contains hyaluronic acid: to correctly interpret its potential it is also important to consider the quantity used, the form used and the quality of the studies conducted on the specific formulation.

It is equally important to distinguish between a substance that performs a physiological function in the body and a supplement that has been clinically proven to produce a specific benefit. The natural presence of a molecule in the tissues does not demonstrate, in itself, that taking greater quantities automatically produces an improvement.

Hyaluronic acid and skin: benefits for hydration, elasticity and wrinkles

The skin is one of the most studied areas for the oral integration of hyaluronic acid. The interest arises from the physiological role of the molecule in skin hydration and from the results obtained in several controlled clinical studies.

The most frequently evaluated aspects include surface hydration, elasticity, water loss through the epidermis and some characteristics of wrinkles.

Skin hydration and dry skin

Well-hydrated skin generally appears softer and more uniform. When the amount of water in the stratum corneum decreases, sensations of tension, roughness and greater evidence of surface lines may appear.

One of the first scientific insights on the subject is represented by the publication Ingested hyaluronan moisturizes dry skin, published in 2014 in the journal Nutrition Journal.

The authors examined studies on the oral intake of hyaluronic acid, reporting favorable results on some skin hydration parameters. The publication contributed to developing interest in this method of integration.

In the following years, further randomized studies were conducted, with different methodologies and dosages.

Skin elasticity and wrinkles: what emerges from the studies?

A meta-analysis published in 2025 in the Journal of Drugs in Dermatology examined seven randomized clinical trials on oral hyaluronic acid supplementation.

The analysis revealed statistically significant improvements, in the groups studied, for some parameters of hydration, elasticity and wrinkle depth. However, equally robust results did not emerge for all the other skin characteristics considered.

An additional randomized, double-blind, placebo-controlled study, published in Scientific Reports in December 2025, involved 150 healthy adults. Participants took sodium hyaluronate at doses of 60 or 120 mg per day or placebo for 12 weeks.

Improvements in some parameters were observed in the group treated with 120 mg, including hydration, elasticity and depth of periocular wrinkles, compared to the placebo. The lower dosage showed generally smaller effects.

These are interesting results, but it is also necessary to consider their limitations: relatively short duration, specific characteristics of the participants and differences between the ingredients used in the various studies.

Does oral hyaluronic acid prevent wrinkles?

It is more correct to talk about research on the possible improvement of certain parameters skin rather than presenting supplements as tools capable of preventing or erasing wrinkles.

Wrinkles depend on several factors: muscle movements, genetics, sun exposure, changes in collagen and elastin, loss of volume and changes in the structure of the skin.

Hydration can especially influence the appearance of more superficial lines, but is not equivalent to the correction of deep wrinkles or sagging tissues.

What is the level of evidence available?

Hyaluronic acid and joints: what do we know about joint wellbeing?

In addition to the skin, hyaluronic acid performs an important function in the joints. It is present in the synovial fluid, a viscous substance that helps to make the movement of the joint surfaces easier and to distribute mechanical stress.

This physiological function has led researchers to study hyaluronic acid also in people with joint discomfort, particularly in the knee.

What do the studies on oral intake say?

A review published in 2016 at Nutrition Journal, available through the National Center for Biotechnology Information, reviewed several studies on oral hyaluronic acid and knee pain.

The studies reviewed included people with varying degrees of joint disorders and used varying formulations and quantities. In some studies, dosages in the range of approximately 80-200 mg per day, used for several weeks, were associated with improvements in specific indicators of pain and function.

A subsequent systematic review, published in 2024 in Mediterranean Journal of Rheumatology, considered 11 studies, for a total of 597 participants.

Nine of the eleven studies reported improvements in at least some assessed parameters. However, the authors highlight the need for further research, especially to better understand which people can benefit from different formulations.

Can a supplement replace treatment for osteoarthritis?

No. Osteoarthritis is a complex joint condition involving cartilage, subchondral bone, synovial membrane and other structures. Its treatment depends on the severity of the symptoms and individual characteristics.

Studies on oral supplementation constitute an interesting line of research, but do not demonstrate that hyaluronic acid in capsules rebuilds cartilage or can replace therapies, therapeutic exercise and medical indications.

In the presence of persistent pain, significant stiffness, swelling or functional limitations, it is advisable to contact a healthcare professional to identify the cause and the best path appropriate.

Hyaluronic acid and gastroesophageal reflux: what relationship exists?

A less known use of hyaluronic acid concerns some formulations intended for the protection of the esophageal mucosa.

In gastroesophageal reflux, the gastric contents can flow back towards the esophagus, causing symptoms such as heartburn and acid regurgitation.

In this context, products containing a combination of hyaluronic acid and chondroitin sulphate, inserted in a bioadhesive formulation designed to temporarily adhere to the mucosa.

One randomized clinical trial published in 2017 involved 154 patients with non-erosive reflux disease. The researchers compared the use of a specific bioadhesive formulation, associated with antisecretory therapy, with that of placebo plus the same therapy.

The improvement expected from the main objective of the study was observed in 52.6% of participants treated with the active formulation, compared to 32.1% of the placebo group.

Also a previous study of 2013, conducted on a smaller sample, had recorded favorable results with a similar combination.

However, it is essential to understand one difference: these studies concern specific oral devices with local action, not common hyaluronic acid supplements intended for nutrition.

It is therefore not correct to automatically transfer the results of reflux formulations to acid capsules hyaluronic acid available as food supplements.

Other uses of hyaluronic acid in medicine and cosmetics

The versatility of hyaluronic acid derives from its physical and biological characteristics. The same molecule can be used in very different products, which respond to specific needs.

Eye drops and ophthalmic preparations

Hyaluronic acid is used in numerous lubricating eye drops intended for the management of dry eye symptoms. Its ability to interact with water and the properties of the formulations contribute to the comfort of the ocular surface.

These products are applied directly to the eye and should not be confused with oral supplements.

Devices for tissue protection and repair

There are dressings and devices containing hyaluronic acid used in particular skin and mucous membrane care contexts. Their function depends on the overall composition of the product and the specific intended use.

In the specialist field, bladder instillations containing hyaluronic acid have also been studied, used in selected clinical situations. These are medical procedures, not normal dietary supplements.

For which conditions is the evidence insufficient?

In the past, oral hyaluronic acid has also been proposed for conditions such as fibromyalgia, insomnia, chronic fatigue, erectile dysfunction and urinary infections.

For these uses, no solid clinical evidence is available that would allow hyaluronic acid supplements to be recommended as a treatment.

The distinction is important: a molecule can participate in numerous physiological processes without oral supplementation being effective for all the conditions in which these processes are involved.

Hyaluronic acid to drink, in capsules, in cosmetics or in fillers: what are the differences?

One of the most frequent questions concerns the difference between hyaluronic acid used in cosmetics and that taken through supplements.

The name of the ingredient is the same, but the method of use, formulation, mechanism of action and objectives change.

High and low molecular weight hyaluronic acid

The molecular weight indicates, in simplified terms, the size of the molecule. It is an important characteristic because it can influence the behavior of hyaluronic acid in formulations.

In cosmetics, high molecular weight forms are particularly appreciated for their ability to contribute to the formation of a hydrating film on the skin surface.

The smaller fractions can present different behaviours, also depending on the cosmetic vehicle used. However, it is not correct to say that any hyaluronic acid with a low molecular weight automatically reaches the deep layers of the dermis.

In supplements, the molecular weight represents a studied variable, but there is no general rule according to which the smallest molecule is always preferable.

How much hyaluronic acid to take per day and after how long?

There is no universal daily dosage of oral hyaluronic acid valid for all people and for any objective.

Clinical studies have used different quantities, also variable depending on the formulation, of the population examined and the parameter to be measured.

In skin research, dosages of 60, 120 and 240 mg per day were studied, among others. In the joint field, different quantities were also used, sometimes within formulas that contained additional ingredients.

These values describe dosages used in the research: they do not represent a general recommendation to start supplementation or to independently increase the quantities indicated by the manufacturer.

After how long can any changes be observed?

Most of the studies on the skin he evaluated periods of several weeks, frequently between six and twelve. Longer periods have also been studied for joints.

Not we must confuse the period necessary to observe a difference in a study with the time within which a person will necessarily notice a benefit.

The possible answer may depend on the initial conditions, individual characteristics, the formula and daily habits.

Is it better to take hyaluronic acid in the morning or in the evening?

There is no convincing evidence demonstrating a general superiority of morning intake compared to evening.

It is preferable to follow the instructions on the label of the specific product, respecting the recommended daily dose and any instructions relating to meals.

Regularity of use is important to respect the intake protocol, but does not justify exceeding the recommended quantities.

How to choose the best hyaluronic acid supplement?

To choose a hyaluronic acid supplement hyaluronic acid it is useful to start from a concrete question: which need do we wish to consider?

One product may contain exclusively hyaluronic acid, while another may combine it with amino acids, vitamins or other ingredients. The formulations are not necessarily interchangeable, because they can be designed with different objectives.

1. Check the quantity of active ingredient

The first information to look for is the quantity of hyaluronic acid present in the recommended daily dose.

The overall weight of a capsule does not necessarily coincide with the quantity of the single active ingredient. A capsule can contain excipients, shell components and multiple substances.

For this reason, a meaningful comparison must be based on the declared milligrams in the daily serving, not just the number of capsules in the package.

2. Consider the source of hyaluronic acid

Hyaluronic acid can be obtained through biotechnological processes, including microbial fermentation, or from certain raw materials of animal origin.

Formulations obtained through fermentation are particularly interesting for those who wish to avoid ingredients derived from animal tissues. However, the sole origin of the hyaluronic acid does not guarantee that the entire supplement is vegan.

It is also necessary to check the composition of the capsule and any other ingredients.

3. Evaluate the associated ingredients

Multi-ingredient formulations allow you to combine substances with different nutritional roles.

Among the ingredients that may be encountered include:

• Vitamin C: contributes to the normal formation of collagen for the normal function of the skin. The use of this health claim is subject to the conditions established by European legislation.
• Amino acids: are the fundamental constituents of proteins and are used in numerous nutritional formulations.
• MSM (methylsulfonylmethane): organic compound containing sulphur, used in some supplements multi-ingredient.
• Coenzyme Q10: substance naturally present in the body, involved in cellular processes of energy production.
• Plant extracts: can provide further components and characterize the formulation.

The presence of more ingredients does not automatically make a product more effective. The evaluation depends on the actual composition, quantities and available evidence.

4. Examine the label, quality and tolerability

A well-presented product should allow you to easily identify the composition, daily dose, method of use, warnings, batch and minimum shelf life.

It is also advisable to check for the presence of any allergens and make sure that the supplement is suitable for your dietary needs.

Practical table for comparing supplements

Acid hyaluronic and amino acids: an FGM04 formulation

Among the possibilities available there are supplements that do not focus on a single ingredient, but bring together different substances in a formulation designed for those who wish to include integration within their routine dedicated to well-being and self-care.

An example is Better Than Collagen 4S by FGM04, a supplement in capsules that combines acid hyaluronic acid, amino acids, MSM, bamboo and other components, including coenzyme Q10 and lycopene.

The formulation also includes acerola, a plant ingredient used as a source of vitamin C.

The physiological role of vitamin C is particularly interesting in the context of skin care, because this vitamin contributes to the normal formation of collagen necessary for normal skin function.

The amino acids instead constitute the fundamental units of proteins. It is useful to point out that a mixture of amino acids is not equivalent, from a structural point of view, to already formed collagen: these are different ingredients, which can be used according to different formulation approaches.

The presence of hyaluronic acid within this combination makes the formula relevant for those interested in the substances naturally present in the extracellular matrix and wish to evaluate a multi-ingredient integration.

This does not imply that the clinical results obtained with individual ingredients are automatically reproducible from their association. For daily quantities, methods of use and warnings, it is always necessary to refer to the label of the formulation purchased.

Hyaluronic acid: side effects, contraindications and precautions

In the available clinical studies, hyaluronic acid taken orally was generally well tolerated by participants. The adverse reactions reported were infrequent and, in most cases, mild.

This data is reassuring, but does not mean that any formulation is risk-free or suitable for all people.

Safety also depends on the quantities taken, the associated ingredients, the duration of use and individual conditions.

What side effects may occur?

Among the possible reactions to consider include gastrointestinal disorders, individual intolerances or allergic manifestations, which may also depend on the other components of the supplement.

It is not correct to automatically attribute the side effects observed with infiltrations or fillers to oral supplements. The methods of administration are different and present different risk profiles.

Allergies and ingredients of animal origin

Some traditional productions of hyaluronic acid used raw materials of animal origin, including cockscombs.

For those with known allergies or who wish to avoid animal components, it is important to verify the origin of the ingredient and the presence of other potential allergens in the formula.

Production through microbial fermentation today allows us to obtain hyaluronic acid without necessarily using these materials prime.

Hyaluronic acid during pregnancy and breastfeeding

The available information does not allow the safety of oral supplementation in pregnant or breastfeeding women to be established with sufficient certainty.

For this reason, in such periods, it is preferable not to start taking it independently and to seek medical advice.

The same caution is appropriate for children and adolescents, considering the absence adequate data for many products intended for adults.

Hyaluronic acid and tumors: what precautions?

The relationship between hyaluronic acid, cell signaling and tumor processes is a scientifically complex topic.

An article published in 2015 has drawn attention to the need for caution in the prolonged use of oral formulations containing hyaluronic acid in people with an oncological history.

This is a precautionary consideration based on hypothesized biological mechanisms, not the clinical demonstration that taking a hyaluronic acid supplement causes tumors or relapses.

People with an ongoing or previous oncological pathology or undergoing specific treatments should in any case consult their doctor before using this type of supplement.

Interactions with drugs and other supplements

Information on the possible drug interactions of oral hyaluronic acid is still limited.

A multi-ingredient formula also requires considering all the components present separately, because precautions may derive from substances other than hyaluronic acid.

If you take drugs continuously, suffer from chronic diseases or use multiple supplements at the same time, it is advisable to ask your doctor or pharmacist for an evaluation.

How to care for your skin from the inside out

Skin care doesn't depend on a single ingredient. Hydration, elasticity and skin appearance are influenced by numerous factors that act together.

For this reason, those who want to keep their skin in good condition should consider a complete routine, capable of combining nutrition, cosmetic treatments and daily habits.

Varied diet and essential nutrients

A balanced diet provides proteins, vitamins, minerals, fatty acids and other nutrients involved in normal functioning of the body.

Vitamin C, for example, contributes to the normal formation of collagen for the normal function of the skin. Food proteins provide the amino acids necessary for the synthesis of the body's proteins.

Hyaluronic acid, on the other hand, is produced physiologically by the body and is not considered an essential nutrient with an established daily requirement.

It is therefore not necessary to take hyaluronic acid daily through food or supplements to avoid a recognized nutritional deficiency.

Moisturizing cosmetics and barrier care skin

Moisturizing creams and serums can help improve the softness of the skin and reduce the sensation of dryness.

Formulations with humectant ingredients, such as hyaluronic acid and glycerin, can be combined with emollient agents and other components useful for maintaining skin comfort.

The choice depends on the skin type: a light texture can be more pleasant for combination skin, while particularly dry skin may require richer formulas.

Sun protection and prevention of photoaging

Protection from ultraviolet rays remains one of the most important strategies to limit photoaging.

The American Academy of Dermatology recommends a broad-spectrum sunscreen with SPF 30 or higher, combined with other protective measures when necessary.

No supplement replaces sunscreen or reverses the damage caused by excessive exposure to UV rays.

Sleep, smoking and daily habits

The quality of sleep, smoking and general lifestyle also deserve attention. These are factors that can influence the state of health and, directly or indirectly, the appearance of the skin.

A constant and realistic approach is more useful than finding a single treatment capable of solving every blemish.

Frequently asked questions about hyaluronic acid supplements

Does hyaluronic acid taken by mouth really work?

Some clinical studies have observed improvements in specific skin and joint parameters following oral intake. The results are promising, but not uniform for all effects studied and cannot be generalized to any product. Further research is needed to better define the effectiveness of the different formulations.

What is the difference between hyaluronic acid and collagen?

Hyaluronic acid is a polysaccharide involved in the hydration and properties of the extracellular matrix. Collagen, on the other hand, is a structural protein present in skin, tendons, ligaments and other tissues. They are two different substances, both important for the organization and characteristics of connective tissues.

Can collagen and hyaluronic acid be taken together?

There are supplements that combine these substances or hyaluronic acid and amino acids. Their presence in the same formula is not in itself a guarantee of greater effectiveness. It is appropriate to evaluate dosages, overall composition, individual needs and any contraindications.

Does hyaluronic acid make you fat?

There is no convincing evidence that oral hyaluronic acid, at the quantities commonly studied, causes an increase in body fat. Weight depends on numerous factors, including energy balance, body composition and individual conditions. Any unexpected changes should not automatically be attributed to this ingredient.

Does hyaluronic acid retain water and cause swelling?

The molecule's ability to interact with water in tissues does not mean that taking it orally will necessarily cause water retention or body swelling. There is no solid evidence linking normal supplement dosages to a systematic increase in fluid retention.

What is the difference between hyaluronic acid and sodium hyaluronate?

Sodium hyaluronate is the sodium salt of hyaluronic acid, frequently used in cosmetics, medical devices and supplements. The two names indicate closely related forms of the same family of molecules. To evaluate a product, the overall formulation counts above all.

Are hyaluronic acid supplements also suitable for men?

There are no reasons to consider hyaluronic acid an exclusively female substance. It is naturally present in the organism of men and women. The possible choice of a supplement should depend on personal needs, composition and health conditions, not on gender.

Is it possible to take hyaluronic acid all year round?

The safety of oral intake for very long periods has not been defined with the same level of detail for all formulations. It is preferable to respect the instructions for use indicated by the manufacturer and consult a healthcare professional when continuous use is expected.

Does a hyaluronic acid supplement replace a moisturizing cream?

No. Oral supplements and cosmetics have different uses and functions. A moisturizing cream acts directly on the skin surface according to the characteristics of its formula, while oral supplementation follows digestive and metabolic processes. The two approaches are not interchangeable.

Which foods contain hyaluronic acid?

Hyaluronic acid is naturally present in animal tissues and can be contained in some food preparations that use them. However, there is no established daily dietary requirement and the amount actually consumed through diet can vary greatly. A balanced diet remains important above all for the overall intake of essential nutrients.

Is a supplement with only hyaluronic acid alone or a complete formula better?

It depends on the goal and personal preferences. A simple formulation allows you to easily identify the individual ingredient. A multi-ingredient formula can be interesting when you want to combine different substances, as long as the composition is transparent and consistent with your needs.

Conclusions: how to correctly evaluate hyaluronic acid supplements

Hyaluronic acid is an important component of our body and performs fundamental functions in the skin, joints and numerous other tissues.

Research on oral supplementation has made interesting progress, especially in the study of hydration skin, elasticity and some parameters linked to the appearance of wrinkles. Joint well-being has also been the subject of studies, although questions remain about the differences between formulations and long-term results.

Whoever wishes to evaluate a supplement should therefore consider the quantity of active ingredient, the associated ingredients, the methods of use and the quality of the information available.

Formulations with hyaluronic acid and other components can be included in a personal routine dedicated to self-care, without replacing good daily habits, skincare and, when necessary, the indications of healthcare professionals.

The most conscious choice does not consist in looking for the product with the greatest number of promises, but in understanding what it contains, how it was formulated and what role it can have within one's habits.

Scientific sources and in-depth studies

The following publications allow us to delve deeper into the results of the research and to distinguish the clinical evidence from the physiological functions of the acid hyaluronic.

1. Kawada C. et al. (2014). Ingested hyaluronan moisturizes dry skin. Nutrition Journal. Review of research on hyaluronic acid taken orally and skin hydration parameters.
   https://pubmed.ncbi.nlm.nih.gov/25014997/
2. Amin P. et al. (2025). Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction. Journal of Drugs in Dermatology. Meta-analysis of seven randomized trials on oral supplementation and skin characteristics.
   https://pubmed.ncbi.nlm.nih.gov/40911749/
3. Dolečková I. et al. (2025). Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults. Scientific Reports. 12-week clinical study with sodium hyaluronate.
   https://pubmed.ncbi.nlm.nih.gov/41422283/
4. Oe M. et al. (2016). Oral hyaluronan relieves knee pain: a review. Nutrition Journal. Review of clinical studies on orally taken hyaluronic acid and knee disorders.
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729158/
5. de Carvalho J.F., Davidson J. (2024). Oral Hyaluronic Acid in Osteoarthritis and Low Back Pain: A Systematic Review. Mediterranean Journal of Rheumatology. Systematic review of 11 clinical studies.
   https://pubmed.ncbi.nlm.nih.gov/39886281/
6. Savarino V. et al. (2017). Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease. Alimentary Pharmacology & Therapeutics. Study on a specific bioadhesive device based on hyaluronic acid and chondroitin sulphate.
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347926/
7. Palmieri B. et al. (2013). Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study. European Review for Medical and Pharmacological Sciences. Clinical study on a formulation for gastroesophageal reflux.
   https://pubmed.ncbi.nlm.nih.gov/24379055/
8. Scientific publication of 2015. Caution should be used in long-term treatment with oral compounds of hyaluronic acid in patients with a history of cancer. In-depth study on the precautions hypothesized for oral use in the presence of a history oncologica.
   https://pubmed.ncbi.nlm.nih.gov/26410544/
9. EFSA (2012). Scientific Opinion on the substantiation of a health claim related to hyaluronic acid and protection of the skin against dehydration. Scientific opinion relating to a specific health claim request.
   https://doi.org/10.2903/j.efsa.2012.2806
10. EFSA (2009). Scientific Opinion on the substantiation of health claims related to hyaluronic acid and maintenance of joints. Scientific evaluation of claims relating to the maintenance of joints.
    https://doi.org/10.2903/j.efsa.2009.1266
11. European Union. Regulation (EU) no. 432/2012. List of permitted health claims, including those related to the role of vitamin C in normal collagen formation.
    https://eur-lex.europa.eu/eli/reg/2012/432/oj
12. American Academy of Dermatology. Practice Safe Sun. Dermatological recommendations on sun protection and prevention of UV-related skin damage.
    https://www.aad.org/public/everyday-care/sun-protection/shade-clothing-sunscreen/practice-safe-sun

Image credits:
Knee pain. Image by jcomp on Freepik.
Doubtful girl. Image by nakaridore on Freepik.